Augmentation Strategies in Patients with Schizophrenia Who Show Partial Response to Clozapine Treatment
نویسندگان
چکیده
منابع مشابه
[Augmentation strategies in patients with schizophrenia who show partial response to clozapine treatment].
A significant proportion of patients with schizophrenia receiving clozapine remain with partial response. In this group of patients findings regarding addition of various psychotropics to ongoing clozapine treatment for augmentation are controversial. In this review, literature regarding the efficacy and safety of adjunctive agents in clozapine resistant schizophrenic patients is examined. Augm...
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BACKGROUND When schizophrenia patients have insufficient response to clozapine, pharmacological augmentation is often applied. This meta-analysis summarizes available evidence on efficacy of pharmacological augmentation of clozapine treatment in schizophrenia spectrum disorder. METHODS Only double-blind randomized controlled studies were included. Primary outcome measure was total symptom sev...
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OBJECTIVE Telomere shortening has been observed in many human diseases, including atherosclerosis, cancer, aging syndromes, Alzheimer disease and vascular dementia. The present study aimed to investigate the mean telomere lengths of patients with schizophrenia. METHODS We analyzed the lengths of telomeric DNA, comparing 2 groups of patients with schizophrenia (34 good responders and 34 poor r...
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BACKGROUND Clozapine (CLZ) is not effective in more than 50% of treatment-resistant schizophrenic patients. In these cases, several pharmacological strategies are used in clinical practice, with different levels of evidence for both safety and efficacy. OBJECTIVES In the present paper we critically reviewed literature data regarding the efficacy and safety of adjunctive agents in CLZ-resistan...
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Clozapine is the only antipsychotic medication that has definitely shown to be effective in treating refractory schizophrenia. Clozapine is typically the medication of choice in schizophrenic patients with a partial response to treatment. When clozapine fails to elicit a full treatment response, augmentation strategies are then explored. It is important to note, however, that in treatment resis...
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ژورنال
عنوان ژورنال: Turkish Journal of Psychiatry
سال: 2014
ISSN: 1300-2163
DOI: 10.5080/u7455